Targeting the g-quadruplex fold of nucleic acids by different computational drug design approaches
23.06.2011
Venue
Sardegna Ricerche
Science and Technology Park of Sardinia
"Giuseppe Pilia" Auditorium, Building 2
Località Piscinamanna
09010 Pula (CA) - Italy
Speaker
Stefano Alcaro - Faculty of Pharmacy and Computational Chemistry Laboratory, "Magna Græcia" University of Catanzaro (Italy)
Description
On 23 June 2011 at 11:00, a seminar entitled "Targeting the g-quadruplex fold of nucleic acids by different computational drug design approaches", organised by Sardegna Ricerche and promoted by the Enterprise Europe Network, will be held at the Technology Park of Sardinia in Pula.
The seminar will illustrate how the G-quadruplex fold is an unusual DNA or RNA conformation adopted in physiological and pathological conditions. The hyper-elongation of the human repeated telomeric sequence folding into this conformation is related to the hyper-proliferation of neoplastic cells. Recently the rationale of blocking the elongation process has been proposed as a new and selective mechanism for developing antitumor agents.
The conformational properties of the G-quadruplex target will be discussed as well as the opportunity to carry out rational design of novel antitumor agents based on the stabilization of this special fold. Details about new computational tools based on different approaches developed in our laboratory will be described with some our G-quadruplex case studies.
The seminar is part of the series "Scientific Seminars in Biomedicine" totalling nine events scheduled from February to October 2011.
The official language of the seminar is English.
Contacts
Patricia Rodriguez Tomè
prtome@crs4.it;
CRS4
Science and Technology Park of Sardinia, Building 1
Località Piscinamanna – 09010 Pula (CA) - Italy
Phone +39 070 9250.387
Sebastiano Baghino
baghino@sardegnaricerche.it;
CINEMA - EEN Branch
Exploitation of Research Results Unit
Sardegna Ricerche, Building 2
Località Piscinamanna - 09010 Pula (CA) - Italy
Phone +39 070 9243.2221 Fax +39 070 9243.2203
Related documents
Seminar poster [file.pdf]
Series schedule - "Scientific Seminars in Biomedicine" (IT) [file.pdf]
Related pages
How to reach the main campus of Sardegna Ricerche;
Sardegna Ricerche
Science and Technology Park of Sardinia
"Giuseppe Pilia" Auditorium, Building 2
Località Piscinamanna
09010 Pula (CA) - Italy
Speaker
Stefano Alcaro - Faculty of Pharmacy and Computational Chemistry Laboratory, "Magna Græcia" University of Catanzaro (Italy)
Description
On 23 June 2011 at 11:00, a seminar entitled "Targeting the g-quadruplex fold of nucleic acids by different computational drug design approaches", organised by Sardegna Ricerche and promoted by the Enterprise Europe Network, will be held at the Technology Park of Sardinia in Pula.
The seminar will illustrate how the G-quadruplex fold is an unusual DNA or RNA conformation adopted in physiological and pathological conditions. The hyper-elongation of the human repeated telomeric sequence folding into this conformation is related to the hyper-proliferation of neoplastic cells. Recently the rationale of blocking the elongation process has been proposed as a new and selective mechanism for developing antitumor agents.
The conformational properties of the G-quadruplex target will be discussed as well as the opportunity to carry out rational design of novel antitumor agents based on the stabilization of this special fold. Details about new computational tools based on different approaches developed in our laboratory will be described with some our G-quadruplex case studies.
The seminar is part of the series "Scientific Seminars in Biomedicine" totalling nine events scheduled from February to October 2011.
The official language of the seminar is English.
Contacts
Patricia Rodriguez Tomè
prtome@crs4.it;CRS4
Science and Technology Park of Sardinia, Building 1
Località Piscinamanna – 09010 Pula (CA) - Italy
Phone +39 070 9250.387
Sebastiano Baghino
baghino@sardegnaricerche.it;CINEMA - EEN Branch
Exploitation of Research Results Unit
Sardegna Ricerche, Building 2
Località Piscinamanna - 09010 Pula (CA) - Italy
Phone +39 070 9243.2221 Fax +39 070 9243.2203
Related documents
Seminar poster [file.pdf]
Series schedule - "Scientific Seminars in Biomedicine" (IT) [file.pdf]
Related pages
How to reach the main campus of Sardegna Ricerche;
